CD31 is a protein found on the surface of endothelial cells (which make blood vessels) and immune cells. It helps cells bind together and is important in managing processes like blood vessel growth and immune response. CD31 is the prime target for researchers because of its role in vascular health and immune system function.
Anti-CD31 antibodies are mainly used in studies to explore the formation of blood vessels, Interactions between immune cells and vessels, and how these processes are involved in diseases like cancer and inflammation.
Go through this post to learn more about how anti-CD31 antibodies are used in vascular and immune research.
Role Of CD31 In Vascular Research
CD31 is an essential molecule used in the study of blood vessels, understanding the formation of blood vessels and the functioning of endothelial cells. Key aspects of vascular research where this plays an important role are:
- Blood Vessel Formation (Angiogenesis):
Angiogenesis is the process by which new blood vessels grow from the existing ones. CD31 helps endothelial cells bind together and form a stable blood vessel structure. Anti-CD31 antibodies help researchers to study the process that targets CD31. It provides a deep understanding of how endothelial cells interact and how blood vessels develop in healthy conditions and in diseases like cancer.
- Endothelial Cells:
Anti-CD31 antibodies are used to identify and isolate endothelial cells. This helps researchers study the structure and health of blood vessels. By targeting CD31, scientists can find vascular permeability (the ability of blood vessels to regulate the flow of substances). These antibodies are also used to study endothelial dysfunction (a condition in which blood vessels lose their ability to function). All these lead to diseases like diabetes and inflammation.
Role Of CD31 In Immune Cell Interaction
CD31 is an important protein involved in immune cell signaling and plays a key role in how immune cells interact with blood vessels during an immune response. Key aspect of how CD31 functions in immune cells and its role in immune research:
- This protein is found on endothelial cells and on some immune cells, like T cells, monocytes, and neurophils. These immune cells protect the body from infections. CD31 regulates the signaling and communication between the immune cells and blood vessels.
- Anti-CD31 antibodies are used to study how immune cells interact with blood vessels, specifically during an immune response. Researchers use these antibodies to learn how immune cells move through the bloodstream and into tissues during inflammation and autoimmune reactions.
Applications Of Anti-CD31 Antibodies In Flow Cytometry And ELISA
- Flow Cytometry:
In this laboratory technique, scientists analyse individual cells by passing them through a laser beam. The laser detects different properties like size, shape, and the presence of protein on the surface of the cell. Anti-CD31 antibodies are used in flow cytometry to recognize endothelial cells.
These antibodies bind to CD31 and help distinguish endothelial cells from other cell types in blood or tissue samples. This allows researchers to study immune cell interactions and how blood vessels function in conditions like inflammation or cancer.
- ELISA (Enzyme-Linked Immunosorbent Assay):
This technique is used to measure the amount of protein in samples like blood, tissue, or fluids. anti-CD31 antibodies help calculate the amount of CD31 protein in the sample. This provides a deep insight into the health of the vascular system and immune response.
For example, a change in the CD31 level shows vascular inflammation (a common condition in tumor angiogenesis). By measuring the CD31 amount in diseased tissue, researchers study the molecular mechanism to understand how diseases like cancer and autoimmune disorders develop.
Final Thought
Anti-CD31 antibodies are essential tools in vascular and immune research. They help researchers study endothelial cells, which make up blood vessel walls, and immune cell interactions, essential in understanding how our immune system works.
By using these antibodies, researchers can find important details about diseases and create more targeted therapies to treat them. If you want to purchase these antibodies, buy from a trusted source like AAA BIO to ensure the accuracy and reliability of your results.
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